SciELO - Scientific Electronic Library Online

 
vol.47 issue4Influence of glucocorticoids on the somatotrophic axisNeuroendocrinology of the metabolic syndrome author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Arquivos Brasileiros de Endocrinologia & Metabologia

On-line version ISSN 1677-9487

Abstract

RODRIGUES, Adriane M.; SUPLICY, Henrique L.  and  RADOMINSKI, Rosana B.. Neuroendocrine control of food intake: implications in the genesis of obesity. Arq Bras Endocrinol Metab [online]. 2003, vol.47, n.4, pp. 398-409. ISSN 1677-9487.  http://dx.doi.org/10.1590/S0004-27302003000400012.

A complex hypothalamic network of hormones and neuropeptides regulates body weight. Mutations in these hormones/peptides, their receptors or regulatory elements, have been described in humans, but they are rare and could not explain the commonest forms of obesity. Nevertheless, the study of these mutations has favored a great progress in the knowledge of genetic basis and physiopathology of obesity, opening new perspectives on the therapeutic approach of this prevalent disease. Recently, mutations in the melanocortin 4 receptor have been found in up to 5% of severe obese subjects, being thus far the most prevalent monogenic form of obesity in humans. In this revision, we discuss the mutations described in some elements of the body weight regulation system in humans, and their implications for the genesis of obesity.

Keywords : Obesity; Genetics; Body weight; Leptin; MC4R; POMC.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf epdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License