Arquivos Brasileiros de Endocrinologia & Metabologia
On-line version ISSN 1677-9487
SAPIENZA, Marcelo Tatit et al. Radioiodine therapy for differentiated thyroid carcinoma: methods used to increase the radiation absorbed dose. Arq Bras Endocrinol Metab [online]. 2005, vol.49, n.3, pp.341-349. ISSN 1677-9487. http://dx.doi.org/10.1590/S0004-27302005000300004.
OBJECTIVES: Our aim was to analyze measures taken to increase the radiation absorbed dose (DOSE) during treatment of well-differentiated thyroid cancer (DTC) with iodine-131. METHODS: An increase in DOSE is achieved by: avoiding competition with non-radioactive iodine, stimulating cellular uptake/retention, increasing the administered activity. Basis and results of each one of these methods were reviewed. RESULTS: Although it is difficult to demonstrate an increase in survival, there is a direct relation between DOSE and tumoral response in DTC. Different approaches can be used aiming an increase in DOSE, with a possible improvement in tumoral response for treatment with iodine-131. Although DTC is a relatively benign disease, a better response to treatment is highly desirable in high-risk patients, who have few other options of therapy. CONCLUSIONS: An increase in DOSE during treatment of DTC can be achieved using the described interventions, which should be used in high-risk cases of DTC.
Keywords : Thyroid cancer; Nuclear medicine; Radionuclide; Thyrotropin; Diet; Dosimetry.