Arquivos Brasileiros de Endocrinologia & Metabologia
versión On-line ISSN 1677-9487
DE ANGELIS, Katia et al. Cardiovascular autonomic dysfunction in experimental diabetes mellitus. Arq Bras Endocrinol Metab [online]. 2007, vol.51, n.2, pp. 185-194. ISSN 1677-9487. http://dx.doi.org/10.1590/S0004-27302007000200007.
Much new information has been published in the last few years regarding pathophysiology of cardiovascular autonomic dysfunction in diabetic rats and mice. Our group has been studying the time-course cardiovascular changes associated with experimental diabetes in the last years, and obtained consistent evidences of severe dysautonomia in diabetes animal models. The aim of this manuscript is to review the contribution that studies involving different animal models of insulin deficiency or resistance have given to understand, treat and prevent diabetic cardiovascular autonomic dysfunction.
Palabras clave : Diabetes mellitus; Autonomic neuropathy; Cardiovascular dysfunction; Animal models.