SciELO - Scientific Electronic Library Online

 
vol.51 issue5Clinical prognosis in BRAF-mutated PTCThyroid carcinoma in children and adolescents author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Arquivos Brasileiros de Endocrinologia & Metabologia

Print version ISSN 0004-2730

Abstract

DEMIDCHIK, Yuri E.; SAENKO, Vladimir A.  and  YAMASHITA, Shunichi. Childhood thyroid cancer in Belarus, Russia, and Ukraine after Chernobyl and at present. Arq Bras Endocrinol Metab [online]. 2007, vol.51, n.5, pp. 748-762. ISSN 0004-2730.  http://dx.doi.org/10.1590/S0004-27302007000500012.

Thyroid cancer in children is usually rare, but in the individuals exposed to radiation risk of disease increases considerably. After the Chernobyl accident in 1986, an over 10-fold maximal elevation in the incidence of thyroid cancer was registered about a decade later, cumulatively resulting in more than a thousand of newly diagnosed cases in children who lived in the territories of Belarus, Russia, and Ukraine affected by radioactive fallouts. Experience from the epidemic substantially promoted knowledge in clinical pediatric oncology, pathology and basic sciences. This article overviews epidemiology, clinical features, results of treatment and follow-up of childhood patients with radiation-induced Chernobyl thyroid cancer in comparison to sporadic cases diagnosed at present. In addition, we discuss general issues of pathology and molecular findings in childhood thyroid carcinomas.

Keywords : Childhood thyroid cancer; Chernobyl; Surgery; Radioiodine; Histotype; Molecular genetics.

        · abstract in Portuguese     · text in English     · pdf in English