Arquivos Brasileiros de Endocrinologia & Metabologia
On-line version ISSN 1677-9487
MACIEL, Rui M.B.. Will the thyroglobulin assay with lower functional sensitivity whilst the patients are on L-T4 treatment replace the TSH-stimulated thyroglobulin assay in the follow-up of patients with differentiated thyroid cancer?. Arq Bras Endocrinol Metab [online]. 2007, vol.51, n.5, pp. 862-866. ISSN 1677-9487. http://dx.doi.org/10.1590/S0004-27302007000500026.
The author reviews the literature on the new assays for serum thyroglobulin (sTg) presenting lower functional sensitivity and demonstrates that its use, whilst the patients are taking L-T4, presents better results than sTg following TSH stimulation in the follow-up of patients with differentiated thyroid carcinoma. Therefore, he suggests a revision on the guidelines for the follow-up of these patients (developed when the available assays present a sensitivity of 1 ng/mL), proposing the use of sTg assays with functional sensitivity of 0.1-0.2 ng/mL with the patients on L-T4 treatment instead of sTg stimulated by TSH.
Keywords : Thyroglobulin; Differentiated thyroid carcinoma; Sensitivity; Functional sensitivity; Stimulated thyroglobulin.