Arquivos Brasileiros de Endocrinologia & Metabologia
versión On-line ISSN 1677-9487
ESTEVES, Roberto Z. et al. Development of a semi-automated method for measuring urinary iodine and its application in epidemiological studies in brazilian schoolchildren. Arq Bras Endocrinol Metab [online]. 2007, vol.51, n.9, pp.1477-1484. ISSN 1677-9487. http://dx.doi.org/10.1590/S0004-27302007000900010.
In this study we developed a semi-automated method for the measurement of urinary iodine using firstly ammonium persulfate for digestion of urine followed by estimation of iodine content in the Sandell-Kolthoff reaction, in which iodine acts as a catalyst for the reduction of cerium. This method was validated in the 3rd Brazilian National Survey of iodine deficiency in 1994. We studied 16,803 casual urine samples from schoolchildren of 401 cities and found 4 moderately-deficient towns (Almas, Arraias, and Parana, in the State of Tocantins, and Cocos, in the State of Bahia), and 116 mildly-deficient. This work suggests that despite the salt iodization program, there was some iodine-deficient areas in Brazil in 1994. Recent surveys, involving less cities, are indicating an excess of iodine ingestion. Therefore, in a country of continental dimensions and very heterogeneous in terms of public health, periodical evaluations are necessary to monitor the real situation of iodine nutrition in Brazil. The method developed in this paper is suitable for these surveys.
Palabras clave : Urinary iodine; Iodine deficiency; Endemic goiter.