Arquivos Brasileiros de Endocrinologia & Metabologia
versión impresa ISSN 0004-2730
CERCATO, Cintia et al. The N363S polymorphism in the glucocorticoid receptor gene: effects on visceral fat assessed by abdominal computed tomography. Arq Bras Endocrinol Metab [online]. 2009, vol.53, n.2, pp. 288-292. ISSN 0004-2730. http://dx.doi.org/10.1590/S0004-27302009000200021.
OBJECTIVE: To verify whether N363S polymorphism of the glucocorticoid receptor-gene can be associated to visceral fat by CT scan in obese individuals, and the impact of this variant on metabolic profile. METHODS: The N363S variant was screened in 295 Brazilians, 195 were obese and 100 presented normal weight. Based on genotype, obese N363S SNP carriers were paired with obese wild-type subjects. This group was submitted to a CT scan and metabolic profile assessment. RESULTS: Ten subjects were found to be heterozygous for the variant (A/G genotype frequency 3.4%), 8 (4.1%) obese and 2 (2.0%) non-obese. No differences were reported for visceral adiposity area (145.8 ± 49.9 vs.147.7 ± 48.8 cm2; p = 0.92) based on CT scan results but N363S SNP carriers showed a proneness to unfavorable metabolic changes. CONCLUSION: The N363S polymorphism prevalence is low in the Brazilian population, although its presence may contribute to the worsening of individuals' metabolic profiles.
Palabras llave : Glucocorticoid; polymorphism; obesity; metabolic syndrome.