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Arquivos Brasileiros de Endocrinologia & Metabologia

On-line version ISSN 1677-9487


ROSARIO, Pedro Weslley; SALLES, Daniela Santos; BESSA, Breno  and  PURISCH, Saulo. Low false-negative rate of cytology in thyroid nodules > 4 cm. Arq Bras Endocrinol Metab [online]. 2009, vol.53, n.9, pp.1143-1145. ISSN 1677-9487.

OBJECTIVE: To report the results of cytology and histology obtained for a series of systematically resected thyroid nodules > 4 cm. METHODS: A group of 151 patients with thyroid nodules > 4 cm was submitted to surgery despite the cytology result. RESULTS: Malignancy was confirmed histologically in 22.5% of the patients. Excluding cases of insufficient material, cytology was benign in only 3/31 carcinomas (90.3% sensitivity). The frequency of malignancy was 35% among nodules with indeterminate cytology (follicular neoplasm), and there was a predominance (77%) of papillary carcinoma. The negative predictive value of benign cytology was 96.4%. CONCLUSIONS: The false-negative rate of cytology in thyroid nodules > 4 cm does not justify systematic resection of these nodules in asymptomatic patients with benign cytology.

Keywords : Thyroid nodule; cytology; benign.

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