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Arquivos Brasileiros de Endocrinologia & Metabologia
versão impressa ISSN 0004-2730
ROSARIO, Pedro Weslley; XAVIER, Arthur Cezar Malard e CALSOLARI, Maria Regina. TSH reference values for adult Brazilian population. Arq Bras Endocrinol Metab [online]. 2010, vol.54, n.7, pp. 603-606. ISSN 0004-2730. http://dx.doi.org/10.1590/S0004-27302010000700003.
OBJECTIVE: To establish limits of normal serum TSH for the adult (18 to 60 years) Brazilian population according to recommendations of the National Academy of Clinical Biochemistry. SUBJECTS AND METHODS: Healthy volunteers were evaluated and those fulfilling the following clinical criteria were selected: absence of known thyroid disease; no use of any interfering medications; no history of head and neck external radiotherapy, type 1 diabetes or autoimmune disease; no family history of thyroid disease, and absence of goiter or palpable nodules. Subjects with anti-thyroperoxidase antibodies and/or altered free T4 were excluded. The sample consisted of 960 subjects (480 males and 480 females). RESULTS: TSH values corresponding to the 2.5th and 97.5th percentiles of the sample were 0.43 and 3.24 mIU/L, respectively. TSH values > 2.5 mIU/L were observed in 9.15% of the volunteers and levels > 3 mIU/L in 3.11%. CONCLUSION: The present study suggests an upper limit of normal TSH of approximately 3.5 mIU/L.
Palavras-chave : TSH; reference values; adult population.