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Arquivos Brasileiros de Endocrinologia & Metabologia

On-line version ISSN 1677-9487


SCHNAIDER-REZEK, Gabrielle Sormanti et al. Metabolic evaluation of young women with congenital adrenal hyperplasia. Arq Bras Endocrinol Metab [online]. 2011, vol.55, n.8, pp.646-652. ISSN 1677-9487.

OBJECTIVE: To evaluate insulin resistance and lipid profile in women with congenital adrenal hyperplasia (CAH) caused by classical 21-hydroxylase deficiency (21OHD), and their association with body mass index (BMI) and corticosteroid dosage. SUBJECTS AND METHODS: We assessed BMI, waist circumference, current glucocorticoid dosage, glucose, insulin and lipid profile in eighteen young women (mean ± SD, 19.3 ± 3.0 years) with 21OHD CAH. RESULTS: BMI was normal in 12 patients, 5 of them were overweight, and 1 was obese. Waist circumference was high in 7 patients. Fasting insulin and HOMA-IR were elevated in seven and eight patients, respectively. Total cholesterol and triglycerides were high in only two patients, and HDL-cholesterol was low in four. Insulin resistance was not associated with BMI, waist circumference or glucocorticoid dose. CONCLUSIONS: Young women with 21OHD CAH had infrequent dyslipidemia, but had a higher prevalence of insulin resistance and central obesity, that were independent of BMI or corticosteroid dosage.

Keywords : Congenital adrenal hyperplasia; insulin resistance; dyslipidemia; obesity.

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