SUMMARY
Clofazimine is a valuable drug for treatment of bacillary infection and for reactional states in leprosy. Side effects include redbrown skin pigmentation, darkening of the skin lesions; red coloration of urine, stools, sputum and sweat; and dryness of the skin and gastro-intestinal symptoms. Conjunctival pigmentation is the most common ocular side effect. Corneal and retinal changes have also been reported. We describe, for the first time, pigmentation of corneal nerves occuring in two patients, with the diagnosis of lepromatous leprosy, treated with clofazimine.
Key-words:
Leprosy; Corneal nerves; Pigmentation; Clofazirnine