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Arquivos Brasileiros de Oftalmologia

Print version ISSN 0004-2749On-line version ISSN 1678-2925

Abstract

NICOLELA, Marcelo Teixeira et al. Effects of ingestion of glycerol on optic disc topography. Arq. Bras. Oftalmol. [online]. 2002, vol.65, n.4, pp.427-429. ISSN 1678-2925.  http://dx.doi.org/10.1590/S0004-27492002000400006.

Purpose: To verify the effects on optic disc topography of newly diagnosed glaucoma subjects after ingestion of glycerol, a drug that causes major changes in both the intra-ocular pressure (IOP) and cerebrospinal fluid pressure (CSFP). Methods: We studied 14 patients presenting with intra-ocular pressure over 25 mmHg, without previous use of hypotensive therapy. Results: Glycerol produced a significant intra-ocular pressure average reduction of 28.2% (95% CI of 20.7 to 32.1%). Despite the obtained intraocular pressure reduction, no significant change was observed in any evaluated topographic parameter (cup area and volume, rim area and volume, maximal and mean cup depth). Conclusions: Overall, no significant change in the topographic parameters, using the "Heildelberg Retina Tomograph", was observed after ingestion of glycerol.

Keywords : Intra-ocular pressure; Optic disc [drug effects]; Optic disc [anatomy & histology]; Glycerol [administration & dosage]; Glaucoma; Tomography.

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