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Arquivos Brasileiros de Oftalmologia

Print version ISSN 0004-2749

Abstract

GONCALVES, Roberto Martins; TEIXEIRA, Antônio Lúcio; CAMPOS, Wesley Ribeiro  and  OREFICE, Fernando. The role of chemokines in uveitis. Arq. Bras. Oftalmol. [online]. 2007, vol.70, n.2, pp. 363-370. ISSN 0004-2749.  http://dx.doi.org/10.1590/S0004-27492007000200033.

Inflammation is part of the physiological process that aims at repairing the damage produced by different causes such as infection, trauma, and autoimmune disease. However, when this physiological process is not regulated, it can contribute to the increase in tissue damage. Chemokines and their receptors are major factors involved in the process of cell migration into inflamed tissues. In the ocular diseases, mainly in uveitis, such proteins have been identified as important mediators of the inflammation process. This review discusses the role of chemokines in several ocular diseases, with emphasis on the uveitic process.

Keywords : Chemokines; Uveitis; Inflammation; Uveal diseases; Review.

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