Arquivos Brasileiros de Oftalmologia
On-line version ISSN 1678-2925
GONCALVES, Roberto Martins; TEIXEIRA, Antônio Lúcio; CAMPOS, Wesley Ribeiro and OREFICE, Fernando. The role of chemokines in uveitis. Arq. Bras. Oftalmol. [online]. 2007, vol.70, n.2, pp. 363-370. ISSN 1678-2925. http://dx.doi.org/10.1590/S0004-27492007000200033.
Inflammation is part of the physiological process that aims at repairing the damage produced by different causes such as infection, trauma, and autoimmune disease. However, when this physiological process is not regulated, it can contribute to the increase in tissue damage. Chemokines and their receptors are major factors involved in the process of cell migration into inflamed tissues. In the ocular diseases, mainly in uveitis, such proteins have been identified as important mediators of the inflammation process. This review discusses the role of chemokines in several ocular diseases, with emphasis on the uveitic process.
Keywords : Chemokines; Uveitis; Inflammation; Uveal diseases; Review.