SciELO - Scientific Electronic Library Online

 
vol.70 issue6Computational simulation of customized photorefractive surgery and precision of correction related to different order aberrationsComparison of two transportation media for study of normal individual conjunctival microbiota author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Arquivos Brasileiros de Oftalmologia

Print version ISSN 0004-2749

Abstract

GAYOSO, Maria de Fátima Azevedo et al. In vitro antimicrobial susceptibility of coagulase negative staphylococcal ocular isolates. Arq. Bras. Oftalmol. [online]. 2007, vol.70, n.6, pp. 924-928. ISSN 0004-2749.  http://dx.doi.org/10.1590/S0004-27492007000600007.

PURPOSE: To assess the in vitro susceptibility of conjunctival and corneal coagulase negative Staphylococcus (CoNS) to methicillin, fluoroquinolones and aminoglycosides. METHODS: A total of 707 conjunctival and corneal CoNS disk diffusion test results were retrospectively analyzed, from January 2000 through December 2003. RESULTS: From 2000 to 2003, there was an increase in number of CoNS isolated from conjunctiva (n=57 to n=153) and cornea (n=28 to n=78). The frequency of conjunctival and corneal methicillin-resistant CoNS also increased (1.8 to 19.6% and 14.3 to 29.3%, respectively). There was no statistically significant difference between fluoroquinolones-resistant CoNS percentages in conjunctiva (ofloxacin: 1.8 to 7.8% and ciprofloxacin: 3.5 to 9.2%) and cornea (ofloxacin: 14.3 to 9.0% and ciprofloxacin: 14.3 to 10.3%). Evaluating the results of the conjunctival samples, there was increased resistance to tobramycin (15.8 to 34.0%) and to gentamycin (10.5 to 25.5%). There was no change in resistance of corneal isolates to tobramycin (28.6 to 26.9%) and to gentamycin (21.4 to 23.1%). CONCLUSIONS: there was a decrease in in vitro CoNS susceptibility to methicillin, tobramycin and gentamycin. Fuoroquinolones represented by ofloxacin and ciprofloxacin demonstrated stable in vitro susceptibility.

Keywords : Drug resistance [microbial]; Eye infections, bacterial [microbiology]; Staphylococcus [isolation & purification]; Coagulase; Fluoroquinolones; Aminoglycosides; Methicillin resistance; Conjunctivitis; Keratitis.

        · abstract in Portuguese     · text in Portuguese     · pdf in Portuguese