Arquivos Brasileiros de Oftalmologia
Print version ISSN 0004-2749
On-line version ISSN 1678-2925
ANDRADE, Eric Pinheiro de; SACAI, Paula Yuri; BEREZOVSKY, Adriana and SALOMAO, Solange Rios. Pattern-reversal visual evoked potential abnormalities in patients with defined multiple sclerosis. Arq. Bras. Oftalmol. [online]. 2007, vol.70, n.6, pp.943-948. ISSN 0004-2749. http://dx.doi.org/10.1590/S0004-27492007000600011.
INTRODUCTION: Multiple sclerosis is an idiopathic demyelinating disease that may affect the optic nerve leading to acute unilateral visual loss, which could be observed by means of evoked visual potential (VEP). This exam is much valued for studying prechiasmatic visual paths in multiple sclerosis. PURPOSE: To analyze the findings of pattern reversal VEP in patients with prior diagnosis of multiple sclerosis and to compare them to visual acuity. METHODS: Twenty-four patients with a definite diagnosis of multiple sclerosis were submitted to pattern reversal VEP from October 2001 to March 2007. RESULTS: In P100 component response, at 15' and 1º stimuli, 19 eyes presented latency response up to 115 ms in both stimuli, which coincided in 6 eyes with latency response between 116 and 135 ms; 11 eyes had a latency response higher than 135 ms, and four eyes did not respond to stimuli. Correlating visual acuity with P100 latency for 15', in Pearson r correlation, r=0.85 with p=0.000000123, and for 1º, r = 0.87 with p=0.0000000338. CONCLUSION: Approximately 60.4% of patients presented abnormalities. However, the correlation between the P100 latency (15' and 1º) and visual acuity was statistically significant; therefore the better the visual acuity, the better the response to stimuli of the pattern-reversal VEP.
Keywords : Demyelinating diseases; Multiple sclerosis; Optic neuritis; Visual acuity; Electrophysiology [methods].