SciELO - Scientific Electronic Library Online

 
vol.70 issue6Treatment outcomes in VI nerve palsy corrected by Carlson & Jampolsky techniqueLong-term results of photorefractive keratectomy for myopia and myopic astigmatism author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Arquivos Brasileiros de Oftalmologia

Print version ISSN 0004-2749

Abstract

BIANCARDI, Ana Luiza et al. Thrombophilic mutations and risk of retinal vein occlusion. Arq. Bras. Oftalmol. [online]. 2007, vol.70, n.6, pp. 971-974. ISSN 0004-2749.  http://dx.doi.org/10.1590/S0004-27492007000600016.

PURPOSE: The association of retinal vein occlusion and hereditary thrombophilia abnormalities is not established, with controversial results in the literature. This study investigates the association between retinal vein occlusion and three thrombophilic mutations: factor V 1691A (factor V Leiden), prothrombin 20210A (PT 20210A) and homozygous methylenetetrahydrofolate reductase 677T (MTHFR 677TT). METHODS: 55 consecutive retinal vein occlusion patients and 55 controls matched by age, gender and race, were tested for the presence of the following mutations: factor V Leiden, PT 20210A and MTHFR 677TT. The frequencies of the three mutations in cases and controls were compared. RESULTS: Factor V Leiden was found in 3.6% of patients and in 0% of controls; PT 20210A was found in 1.8% of patients and 3.6% of controls, (matched-pair odds ratio, 0.5; 95% confidence interval, 0.04 to 5.51); MTHFR 677TT was found in 9% of patients and 9% of controls (matched-pair odds ratio, 1; 95% confidence interval, 0.92 to 3.45). Arterial hypertension was more frequent in patients than controls (matched-pair odds ratio, 3.4; 95% confidence interval, 1.25 to 9.21). CONCLUSIONS: This study suggests that thrombophilic mutations are not risk factors for RVO. Routine investigation of hereditary thrombophilia in these patients is not justified.

Keywords : Retinal vein occlusion; Risk factors; Thrombophilia; Factor V; Prothrombin; Methylenetetrahydrofolate reductase (NADPH2).

        · abstract in Portuguese     · text in English     · pdf in English