Arquivos Brasileiros de Oftalmologia
On-line version ISSN 1678-2925
QUINTO, Guilherme Goulart; CAMPOS, Mauro and BEHRENS, Ashley. Autologous serum for ocular surface diseases. Arq. Bras. Oftalmol. [online]. 2008, vol.71, n.6, suppl., pp. 47-54. ISSN 1678-2925. http://dx.doi.org/10.1590/S0004-27492008000700010.
Autologous serum has been used to treat dry eye syndrome for many years. It contains several growth factors, vitamins, fibronectin and other components that have been considered important for corneal and conjunctival integrity. Serum eye drops are usually prepared as an unpreserved blood solution. The serum is by nature well tolerated and its biochemical properties are somewhat similar to natural tears. Autologous serum eye drops have been reported to be effective for the treatment of severe dry eye-related ocular surface disorders (Sjögren's syndrome), and also other entities such as superior limbic keratoconjunctivitis, graft-versus-host disease, Stevens-Johnson syndrome, ocular cicatricial pemphigoid, recurrent or persistent corneal erosions, neurotrophic keratopathy, Mooren's ulcer, aniridic keratopathy, filtering blebs after trabeculectomy, and post-keratorefractive surgery. The purpose of this study is to review the recently published literature on ocular surface diseases treated with human autologous serum eye drops.
Keywords : Corneal diseases [therapy]; Conjunctival diseases [therapy]; Lacrimal apparatus [abnormalities]; Serum; Ophthalmic solutions [therapeutic use].