SciELO - Scientific Electronic Library Online

 
vol.75 número3Contaminação viral durante cirurgias sequenciais de facoemulsificação em um modelo experimentalCorrelação entre a espessura do subcampo central, a acuidade visual e mudanças estruturais no edema macular diabético índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Artigo

Indicadores

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Arquivos Brasileiros de Oftalmologia

versão impressa ISSN 0004-2749

Resumo

FADLALLAH, Ali et al. Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis. Arq. Bras. Oftalmol. [online]. 2012, vol.75, n.3, pp. 178-182. ISSN 0004-2749.  http://dx.doi.org/10.1590/S0004-27492012000300006.

PURPOSE: To assess the efficacy of topical 1.5% azithromycin in the treatment of moderate to severe chronic blepharitis and to compare the efficacy of two different treatment modalities. METHODS: A randomized clinical trial included 67 patients with chronic anterior and/or posterior blepharitis, followed-up for 3 months. Signs and symptoms were graded according to severity. Patients were randomized into two groups: 33 patients in group I and 34 patients in group II. Group I patients were treated with topical 1.5% azithromycin twice a day for three days, and Group II patients were treated with topical 1.5% azithromycin twice a day for three days then at bedtime for the rest of the month. All patients were instructed to apply warm compresses and an eye-friendly soap twice daily. RESULTS: Patients in both groups tolerated the treatment with minimal irritation. A significant improvement in signs and symptoms was noted at the one week follow-up visit. Group II showed a more pronounced and longer-lasting improvement that persisted after three months of follow-up. CONCLUSION: Topical 1.5% azithromycin ophthalmic solution is an effective treatment option for chronic blepharitis. In moderate to severe blepharitis, a one month treatment is safe and shows better improvement than the three-day protocol with no significant relapse until three months of follow-up.

Palavras-chave : Azithromycin [administration & dosage]; Blepharitis [drug therapy]; Chronic disease; Ophthalmic solutions; Meibomian glands.

        · resumo em Português     · texto em Inglês     · pdf em Inglês