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Arquivos Brasileiros de Oftalmologia

Print version ISSN 0004-2749

Abstract

REGGI, José Ricardo de Abreu et al. Subconjunctival and topical application of recombinant tissue plasminogen activator in rabbits. Arq. Bras. Oftalmol. [online]. 2015, vol.78, n.1, pp.6-9. ISSN 0004-2749.  https://doi.org/10.5935/0004-2749.20150003.

Purpose:

To quantify fibrin degradation products after topical and subconjunctival administration of recombinant tissue plasminogen activator in rabbits.

Methods:

Fibrin formation was induced in the anterior chamber in 25 rabbits. Subsequently, five rabbits received an injection of r-TPA (positive control) in the anterior chamber, another 10 received a subconjunctival injection of r-TPA, and the remaining 10 received instillations of topical r-TPA. Afterwards, samples of aqueous humor were collected and semi-quantitative analysis of fibrin degradation products (FDP) was performed.

Results:

No statistical differences were noted between the treatment and control groups at any time point. Fibrin degradation products semi-quantification showed statistical improvement in the control group and the subconjunctival group.

Conclusion:

Fibrin degradation products were observed in the anterior chamber after subconjunctival administration of r-TPA. However, it was probably not sufficient to cause fibrin degradation. Topical r-TPA did not effectively absorb anterior chamber fibrin.

Keywords : Tissue plasminogen activator; Anterior chamber; Hyphema; Inflammation; Postoperative complications; Animals; Rabbits.

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