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Arquivos de Gastroenterologia

Print version ISSN 0004-2803On-line version ISSN 1678-4219

Abstract

ANGELIS, Rebeca C de et al. Enhancement of sodium intestinal secretion in relation to absorption in malnourished rats: hyperosmolar challenge. Arq. Gastroenterol. [online]. 1999, vol.36, n.4, pp.220-226. ISSN 1678-4219.  http://dx.doi.org/10.1590/S0004-28031999000400010.

Two experimental models were tried in young malnourished rats in order to study effect of an hyperosmolar challenge in the small intestine on the bi-directional fluxes of sodium. Weanling rats were fed with energy restricted diets. In model I 1 mL of NaCl 900 mOsm/kg was introduced in the small intestine of the rats and left from 5 up to 70 min, in order to determine the moment of higher net Na+ secretion, which occurred at 10 min. In model II, the bi-directional fluxes of Na+ and Cl- were studied using NaCl or mannitol 900 mOsm/kg under the effect of mecholil, atropine or 2-4 dinitrophenol, for 10 min. Mecholil decreased the Na+ absorption enhancing the net secretion. Control rats were used as reference. In the restricted diets animals occurred an increase of the net secretion stimulated by NaCl 900 mOsm/kg, and this effect was enhanced by mecholil. It is suggested that in malnutrition there is an impairment in Na- intestinal absorption.

Keywords : Intestinal secretions; Nutrition disorders; Sodium; Intestinal absorption; Rats.

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