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Arquivos de Gastroenterologia

Print version ISSN 0004-2803On-line version ISSN 1678-4219

Abstract

COURA, Renata dos Santos; ASHTON-PROLLA, Patricia  and  PROLLA, João Carlos. Hereditary non-polipomatous colorectal cancer: hereditary predisposition, diagnosis and prevention. Arq. Gastroenterol. [online]. 2005, vol.42, n.2, pp.99-106. ISSN 1678-4219.  http://dx.doi.org/10.1590/S0004-28032005000200007.

BACKGROUND: Colorectal cancer is the third in frequency and the second in mortality in developed countries. In Brazil, it is among the six more common malignant neoplasias. About 20% of colorectal tumors have some hereditary component. AIM: This study presents a review of genetic and clinic aspects, as well as diagnosis and prevention of the hereditary non-polipomatous colorectal cancer, that is the more frequent form of hereditary colorectal cancer. This approach is important because, currently there are possibilities of management, prevention and surveillance specific to individuals at-risk for hereditary non-polipomatous colorectal cancer that can lead to a great improvement in patients' survival and their at-risk relatives.

Keywords : Colonic neoplasms [genetics]; Colorectal neoplasms, hereditary nonpolyposis; Heredity.

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