SciELO - Scientific Electronic Library Online

 
vol.49 issue3Weight loss during cirrhosis is related to the etiology of liver diseaseCeliac disease in first degree relatives of celiac children author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Arquivos de Gastroenterologia

Print version ISSN 0004-2803

Abstract

NASS, Flávia Raphaela et al. Autoantibodies in relatives of celiac disease patients: a follow-up of 6-10 years. Arq. Gastroenterol. [online]. 2012, vol.49, n.3, pp. 199-203. ISSN 0004-2803.  http://dx.doi.org/10.1590/S0004-28032012000300006.

CONTEXT: Autoimmune diseases are 3 to 10 times more frequently in patients with celiac disease and their relatives than in the general population. OBJECTIVE: To investigate a broad spectrum of autoantibodies in celiac disease relatives from Southern Brazil, in a serological follow-up of 6-10 years, aiming to associate with other autoimmune diseases, degree of parentage, demographic and clinical data. METHODS: Serum samples of 233 relatives were analyzed in two different phases: n = 186 in phase I (1997-2000) and n = 138 (being 91 = follow-up group and 47 = newly tested) in phase II (2006-2007). As controls, 100 unrelated individuals were evaluated. Autoantibodies to smooth muscle, mitochondrial, liver-kidney microssome, parietal cell and thyroid microssome were tested by indirect immunofluorescence. RESULTS: A significant increase of autoantibodies, in both phases, was observed in the relatives when compared to the non-relatives (P = 0.0064), specifically to anti-thyroid microssome and anti-parietal cell. In both phases, the female/male proportion of autoantibodies was of 4:1 to 3:1 (P<0.041). The frequency of autoantibodies amongst 1st and 2nd degree relatives was 11.8% and 9.68% in phase I and 4% and 6.67% in phase II. CONCLUSION: Celiac disease relatives presented other autoantibodies and serological screening is a useful instrument for identifying autoimmune diseases along the years.

Keywords : Autoantibodies; Celiac disease; Autoimmune diseases; Family.

        · abstract in Portuguese     · text in English     · pdf in English