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vol.51 issue1SURGICAL OUTCOMES AND PROGNOSTIC FACTORS IN PATIENTS WITH SYNCHRONOUS COLORECTAL LIVER METASTASESEXHALED AND PLASMA NITRITE: a comparative study among healthy, cirrhotic and liver transplant patients author indexsubject indexarticles search
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Arquivos de Gastroenterologia

Print version ISSN 0004-2803

Abstract

PORT, Gabriela Zanatta; OLIVEIRA, Kalinca; SOLDERA, Jonathan  and  TOVO, Cristiane Valle. BIOCHEMICAL NUTRITIONAL PROFILE OF LIVER CIRRHOSIS PATIENTS WITH HEPATOCELLULAR CARCINOMA. Arq. Gastroenterol. [online]. 2014, vol.51, n.1, pp.10-15. ISSN 0004-2803.  http://dx.doi.org/10.1590/S0004-28032014000100003.

Context

Liver cirrhosis patients with hepatocellular carcinoma present nutritional alterations and metabolic disorders that negatively impact the prognosis.

Objective

The objective is to identify alterations in the metabolism of macro and micronutrients among liver cirrhosis patients with and without hepatocellular carcinoma and their relation to the Child-Turcote-Pugh score and Barcelona Clinic Liver Cancer staging.

Methods

Analytical transversal study, with 31 hepatocellular carcinoma patients and 48 liver cirrhosis patients. Laboratorial exams were carried out. The existence of an association between the biochemical parameters and the disease severity as well as the presence of hepatocellular carcinoma was assessed.

Results

The metabolic-nutritional profile of liver cirrhosis patients caused by the hepatitis C virus and hepatocellular carcinoma showed alterations, specifically the lipid (total cholesterol, HDL and triglycerides), protein (albumin, creatinine and uric acid), iron (transferrin, iron and ferritin saturation), hematocrit and hemoglobin, zinc and B12 vitamin profiles. There is a relation between nutritional biochemical markers and the Child-Turcote-Pugh, as well as Barcelona Clinic Liver Cancer staging.

Conclusions

Considering the existence of alterations in the metabolism of nutrients in liver cirrhosis patients with and without hepatocellular carcinoma, and also that conventional nutritional assessment methods present limitations for this population, the biochemical laboratorial exams are valid to complement the diagnosis of the nutritional state in a quick and practical manner.

Keywords : Liver cirrhosis; Hepatocellular carcinoma; Malnutrition; Nutritional assessment; Hepacivirus.

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