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vol.51 issue1ANTI-ULCER ACTIVITY OF LEGUMINOSAE PLANTSHEPATITIS AND PNEUMONITIS DURIN ADALIMUMAB THERAPY IN CROHN’ DISEASE: mind the histoplasmosis! author indexsubject indexarticles search
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Arquivos de Gastroenterologia

Print version ISSN 0004-2803

Abstract

SOUSA, Rita G et al. COLONOSCOPY AND CARCINOEMBRYONIC ANTIGEN VARIATIONS. Arq. Gastroenterol. [online]. 2014, vol.51, n.1, pp.69-72. ISSN 0004-2803.  https://doi.org/10.1590/S0004-28032014000100014.

Context

Colonoscopy is essential for synchronous and metachronous cancer detection. Carcinoembryonic antigen is a colorectal cancer tumor marker, important as a follow-up tool in patients with previous colorectal cancer. False-positive carcinoembryonic antigen elevation results in multiples exams and in patient anxiety. In literature, there is reference to transient carcinoembryonic antigen increase with colonoscopy.

Objective

To evaluate the influence of bowel preparation and colonoscopy in carcinoembryonic antigen blood levels.

Methods

We prospectively studied subjects that underwent routine colonoscopy in our institution. Blood samples were collected (1) before bowel cleaning, (2) before colonoscopy and (3) immediately after colonoscopy. Blood carcinoembryonic antigen levels were determined by “Sandwich” immunoassay. The statistical methods used were the paired t-test and ANOVA.

Results

Thirty-seven patients (22M/15F) were included; age range 28-84 (mean 56 years). Mean carcinoembryonic antigen values were 1.9, 2 and 1.8 for (1), (2) and (3), respectively. An increase in value (2) compared with (1) was observed in 20/37 patients (P = 0.018), mainly in younger patients and in patients requiring more endoluminal interventions. In 29/37 patients, the CEA value decreased from (2) to (3) (P = 1.3x10-7).

Conclusions

A trend for carcinoembryonic antigen increase after bowel cleaning was observed, especially in younger patients and in patients with more endoluminal interventions, but without clinical meaning.

Keywords : Colonoscopy, methods; Carcinoembryonic antigen; Colorectal neoplasms.

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