Macarthur 20052222. Macarthur M, Sharp L, Hold GL, Little J, El-Omar EM. The Role of Cytokine Gene Polymorphisms in Colorectal Cancer and Their Interaction with Aspirin Use in the Northeast of Scotland. Cancer Epidemiol Biomarkers Prev. 2005;14:1613-8.
|
Scotland (Caucasian) |
PB |
TaqMan |
257/403 |
61 |
125 |
71 |
247 |
267 |
86 |
202 |
115 |
374 |
432 |
0.536 |
0.877 |
Crivello 20062323. Crivello A, Giacalone A, Vaglica M, Scola L, Forte GI, Macaluso MC, et al. Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma. Ann N Y Acad Sci. 2006;1089:98-103.
|
Italy (Caucasian) |
PB |
ARMS-PCR |
62/124 |
16 |
34 |
12 |
66 |
58 |
38 |
60 |
26 |
136 |
112 |
0.451 |
0.796 |
Guntar 20062424. Gunter MJ, Canzian F, Landi S, Chanock SJ, Sinha R, Rothman N. Inflammation-Related Gene Polymorphisms and Colorectal Adenoma. Cancer Epidemiol Biomarkers Prev . 2006;15:1126-31.
|
USA (Caucasian) |
HB |
TaqMan |
222/207 |
61 |
114 |
47 |
236 |
208 |
55 |
123 |
29 |
233 |
181 |
0.437 |
0.002 |
Cozar 2007 2525. Cozar JM, Romero JM, Aptsiauri N, Vazquez F, Vilchez JR, Tallada M, et al. High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer. Hum Immunol. 2007;68:698-704.
|
Spain (Caucasian) |
PB |
TaqMan |
126/175 |
42 |
62 |
22 |
146 |
106 |
58 |
87 |
30 |
203 |
147 |
0.420 |
0.787 |
Talseth 20072626. Talseth BA, Meldrum C, Suchy J, Kurzawski G, Lubinski J, Scott RJ. Lack of association between genetic polymorphisms in cytokine genes and disease expression in patients with hereditary non-polyposis colorectal cancer. Scand J Gastroenterol. 2007;42:628-32.
|
Mixed (Caucasian)* |
HB |
Sequencing |
118/100 |
36 |
61 |
21 |
133 |
103 |
33 |
50 |
17 |
116 |
84 |
0.420 |
0.792 |
Wilkening 20082727. Wilkening S, Tavelin B, Canzian F, Enquist K, Palmqvist R, Altieri A, et al. Interleukin promoter polymorphisms and prognosis in colorectal cancer. Carcinogenesis. 2008;29:1202-6.
|
Sweden (Caucasian) |
PB |
TaqMan |
304/579 |
83 |
146 |
75 |
312 |
296 |
164 |
283 |
132 |
611 |
547 |
0.472 |
0.639 |
Cacev 20082828. Cacev T, Radosević S, Krizanac S, Kapitanović S. Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression. Carcinogenesis. 2008;29:1572-80.
|
Croatia (Caucasian) |
PB |
TaqMan |
160/160 |
54 |
86 |
20 |
194 |
126 |
43 |
92 |
25 |
178 |
142 |
0.443 |
0.037 |
Tsilidis 2009 2929. Tsilidis KK, Helzlsouer KJ, Smith MW, Grinberg V, Hoffman-Bolton J, Clipp SL, et al. Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. Cancer Causes Control . 2009;20:1739-51.
|
USA (Caucasian) |
PB |
TaqMan |
205/372 |
69 |
101 |
35 |
239 |
171 |
98 |
187 |
87 |
383 |
361 |
0.485 |
0.903 |
Miteva 20143030. Miteva LD, Stanilov NS, Deliysky TS, Stanilova SA. Significance of -1082A/G polymorphism of IL10 gene for progression of colorectal cancer and IL-10 expression. Tumour Biol. 2014;35:12655-64.
|
Bulgaria (Caucasian) |
PB |
ARMS-PCR |
119/154 |
40 |
57 |
22 |
137 |
101 |
54 |
79 |
21 |
187 |
121 |
0.392 |
0.349 |
Burada 20133131. Burada F, Dumitrescu T, Nicoli R, Ciurea ME, Rogoveanu I, Ioana M. Cytokine promoter polymorphisms and risk of colorectal cancer. Clin Lab. 2013;59:773-9.
|
Romania (Caucasian) |
HB |
TaqMan |
144/233 |
65 |
60 |
19 |
190 |
98 |
80 |
118 |
35 |
278 |
188 |
0.403 |
0.426 |
Basavaraju 20153232. Basavaraju U, Shebl FM, Palmer AJ, Berry S, Hold GL, El-Omar EM, et al. Cytokine gene polymorphisms, cytokine levels and the risk of colorectal neoplasia in a screened population of Northeast Scotland. Eur J Cancer Prev . 2015;24:296-304.
|
Scotland (Caucasian) |
PB |
TaqMan |
388/496 |
58 |
210 |
92 |
351 |
394 |
103 |
261 |
130 |
471 |
521 |
0.527 |
0.183 |
Li 20153333. Li HX, Li YY, Song ZJ, He SX, Guo QY. Association between IL-8-251A/T and il-10-1082A/G genetic polymorphisms and susceptibility to colorectal cancer: A case-control study in a population in Shaanxi. World Chinese J Dig. 2015;23:1184-90.
|
China (Asian) |
HB |
AS-PCR |
102/105 |
26 |
66 |
10 |
118 |
86 |
20 |
77 |
8 |
117 |
93 |
0.442 |
≤0.001 |
Cai 20163434. Cai J, Zhang Z. An Analysis of IL-10/IL-10R Genetic Factors Related to Risk of Colon Cancer and Inflammatory Bowel Disease in a Han Chinese Population. Clin Lab. 2016;62:1147-54.
|
China (Asian) |
HB |
MassARRAY |
375/382 |
323 |
50 |
2 |
696 |
54 |
343 |
39 |
0 |
725 |
39 |
0.051 |
0.293 |
Gulubova 20183535. Gulubova M, Aleksandrova E, Vlaykova T. Promoter polymorphisms in TGFB1 and IL10 genes influence tumor dendritic cells infiltration, development and prognosis of colorectal cancer. J Gene Med. 2018;e3005.
|
Bulgaria (Caucasian) |
NS |
ARMS-PCR |
120/159 |
47 |
57 |
16 |
151 |
89 |
59 |
78 |
22 |
196 |
122 |
0.383 |
0.638 |
IL-10 -592C>A (rs1800872)
|
|
|
|
|
CC
|
AC
|
AA
|
C |
A |
CC
|
AC
|
AA
|
C |
A |
|
|
Macarthur 20052222. Macarthur M, Sharp L, Hold GL, Little J, El-Omar EM. The Role of Cytokine Gene Polymorphisms in Colorectal Cancer and Their Interaction with Aspirin Use in the Northeast of Scotland. Cancer Epidemiol Biomarkers Prev. 2005;14:1613-8.
|
Scotland (Caucasian) |
PB |
TaqMan |
258/403 |
151 |
99 |
8 |
401 |
115 |
248 |
133 |
22 |
629 |
177 |
0.219 |
0.455 |
Crivello 20062323. Crivello A, Giacalone A, Vaglica M, Scola L, Forte GI, Macaluso MC, et al. Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma. Ann N Y Acad Sci. 2006;1089:98-103.
|
Italy (Caucasian) |
PB |
ARMS-PCR |
62/124 |
31 |
28 |
3 |
90 |
34 |
69 |
48 |
7 |
186 |
62 |
0.250 |
0.719 |
Talseth 20072626. Talseth BA, Meldrum C, Suchy J, Kurzawski G, Lubinski J, Scott RJ. Lack of association between genetic polymorphisms in cytokine genes and disease expression in patients with hereditary non-polyposis colorectal cancer. Scand J Gastroenterol. 2007;42:628-32.
|
Mixed (Caucasian) |
HB |
Sequencing |
117/99 |
62 |
51 |
4 |
175 |
59 |
50 |
45 |
4 |
145 |
53 |
0.267 |
0.112 |
Vogel 20073636. Vogel U, Christensen J, Dybdahl M, Friis S, Hansen RD, Wallin H, et al. Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer. Mutat Res. 2007;624:88-100.
|
Danish (Caucasian) |
PB |
TaqMan |
355/753 |
224 |
109 |
22 |
557 |
153 |
455 |
256 |
42 |
1166 |
340 |
0.225 |
0.450 |
Cozar 20072525. Cozar JM, Romero JM, Aptsiauri N, Vazquez F, Vilchez JR, Tallada M, et al. High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer. Hum Immunol. 2007;68:698-704.
|
Spain (Caucasian) |
PB |
TaqMan |
95/175 |
52 |
41 |
2 |
145 |
45 |
98 |
63 |
14 |
259 |
91 |
0.260 |
0.393 |
Cacev 20082828. Cacev T, Radosević S, Krizanac S, Kapitanović S. Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression. Carcinogenesis. 2008;29:1572-80.
|
Croatia (Caucasian) |
PB |
PCR-RFLP |
160/160 |
83 |
64 |
13 |
230 |
90 |
104 |
52 |
4 |
260 |
60 |
0.187 |
0.399 |
Tsilidis 20092929. Tsilidis KK, Helzlsouer KJ, Smith MW, Grinberg V, Hoffman-Bolton J, Clipp SL, et al. Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. Cancer Causes Control . 2009;20:1739-51.
|
USA (Caucasian) |
PB |
TaqMan |
203/361 |
123 |
71 |
9 |
317 |
89 |
213 |
131 |
17 |
557 |
165 |
0.228 |
0.579 |
Andersen 20123636. Vogel U, Christensen J, Dybdahl M, Friis S, Hansen RD, Wallin H, et al. Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer. Mutat Res. 2007;624:88-100.
|
Danish (Caucasian) |
PB |
KASP assay |
949/1748 |
596 |
297 |
56 |
1489 |
409 |
1072 |
580 |
96 |
2724 |
772 |
0.226 |
0.134 |
Yu 20143838. Yu Y, Zheng S, Zhang S, Jin W, Liu H, Jin M, et al. Polymorphisms of inflammation-related genes and colorectal cancer risk: a population-based case-control study in China. Int J Immunogenet. 2014;41:289-97.
|
China (Asian) |
PB |
PCR-RFLP |
298/291 |
153 |
114 |
31 |
420 |
176 |
118 |
135 |
38 |
371 |
211 |
0.362 |
0.949 |
Basavaraju 20153232. Basavaraju U, Shebl FM, Palmer AJ, Berry S, Hold GL, El-Omar EM, et al. Cytokine gene polymorphisms, cytokine levels and the risk of colorectal neoplasia in a screened population of Northeast Scotland. Eur J Cancer Prev . 2015;24:296-304.
|
Scotland (Caucasian) |
HB |
TaqMan |
387/496 |
241 |
134 |
12 |
616 |
158 |
311 |
168 |
17 |
790 |
202 |
0.203 |
0.323 |
Cai 20163434. Cai J, Zhang Z. An Analysis of IL-10/IL-10R Genetic Factors Related to Risk of Colon Cancer and Inflammatory Bowel Disease in a Han Chinese Population. Clin Lab. 2016;62:1147-54.
|
China (Asian) |
HB |
MassARRAY |
375/382 |
221 |
128 |
26 |
570 |
180 |
184 |
158 |
40 |
526 |
238 |
0.311 |
0.484 |
IL-10 -819T>C (rs1800871)
|
|
|
|
|
TT
|
TC
|
CC
|
T
|
C |
TT
|
TC
|
CC
|
T
|
C
|
|
|
Guntar 20062424. Gunter MJ, Canzian F, Landi S, Chanock SJ, Sinha R, Rothman N. Inflammation-Related Gene Polymorphisms and Colorectal Adenoma. Cancer Epidemiol Biomarkers Prev . 2006;15:1126-31.
|
USA (Caucasian) |
HB |
TaqMan |
222/209 |
125 |
76 |
21 |
326 |
118 |
117 |
79 |
13 |
313 |
105 |
0.251 |
0.944 |
Cozar 2007 2525. Cozar JM, Romero JM, Aptsiauri N, Vazquez F, Vilchez JR, Tallada M, et al. High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer. Hum Immunol. 2007;68:698-704.
|
Spain (Caucasian) |
PB |
TaqMan |
95/175 |
81 |
37 |
9 |
199 |
55 |
98 |
63 |
14 |
259 |
91 |
0.260 |
0.393 |
Cacev 2008 2828. Cacev T, Radosević S, Krizanac S, Kapitanović S. Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression. Carcinogenesis. 2008;29:1572-80.
|
Croatia (Caucasian) |
PB |
PCR-RFLP |
160/160 |
83 |
64 |
13 |
230 |
90 |
106 |
51 |
3 |
263 |
57 |
0.178 |
0.262 |