Arquivos de Neuro-Psiquiatria
Print version ISSN 0004-282X
SIQUEIRA, Mario G.; VIEIRA, Ivoney A.; CILIAO, Elizeu A. and GUERRA, Dora M. G.. Saccular aneurysms: experimental evaluation of the efficacy of an intra-vascular therapeutic procedure. Arq. Neuro-Psiquiatr. [online]. 1980, vol.38, n.1, pp.24-32. ISSN 0004-282X. http://dx.doi.org/10.1590/S0004-282X1980000100004.
Studies were performed on adult mongrel dogs to evaluate the possibility of occluding saccular aneurysms with an intravascular injection of the tissue adhesive Bucrylat (isobutyl-2-cyanoacrylate). Fourteen surgically constructed carotid aneurysms were occluded by the injection of Bucrylat through a fluoroscopically positioned intra-arterial catheter. Angiography performed immediately before and after injection and up to 1 month following treatment revealed progressive and persistent occlusion of the aneurysms. The specimens examined histologically 1 month after the injection showed an endothelialized fibrous tissue bridge crossing the neck of the aneurysm what appear to indicate a permanent occlusion of the structures treated. A similar approach to treat intracranial aneurysms will depend on advances in the field of selective intracranial catheterization that will permit safe and accurate catheterization of the aneurysm sac.