SciELO - Scientific Electronic Library Online

 
vol.47 issue2Oligodendroglioma of the cerebello pontine angle: 16 years evolution. Literature revision and comments about the pathology author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Abstract

DIAS-TOSTA, Elza; AGUIAR, Maria de Fátima Machado; BARBOSA, Hamilton  and  VILELA, Suzete Silva Leme. Familial myasthenia gravis: case report in identical twins. Arq. Neuro-Psiquiatr. [online]. 1989, vol.47, n.2, pp.248-253. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X1989000200019.

To the best of our knowledge this is the seventh case report of monozygotic twins both affected by myasthenia gravis (MG). The monozygotism was proven by sex identity, blood group and HLA determinations ('O' Rh +, A2, A19.2, B40, CW3). One paternal aunt was also affected and the three cases have high titles of anti-acetylcholine receptor antibodies and anti-striated muscle antibodies, which indicate an acquired form of MG. After several myasthenic crises the twins are now doing well with corticosteroid therapy. The paternal aunt has a more benign form of MG, with ocular and limb involvement (grade IIa of Osserman) and was submitted to thymectomy. The authors discuss the use of corticosteroid for the infantile form of MG instead of thymectomy, based on the immaturity of the immune system in the young age. The use of other immunosupressive drugs is not advisable because of potential hazardous development of neoplasms.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License