SciELO - Scientific Electronic Library Online

vol.52 issue2Dichotic words listening test: technical aspects and results in normal right-handed individualsElevated levels of soluble interleukin-2 receptors in multiple sclerosis: preliminary report on 26 patients author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X


LEITE, Silmara A.O. et al. Carbamazepine kinetics in cardiac patients before and during amiodarone. Arq. Neuro-Psiquiatr. [online]. 1994, vol.52, n.2, pp.210-215. ISSN 0004-282X.

Carbamazepine and amiodarone may often be used together, especially in countries where cardiomyopathies are common. In this study single doses of carbamazepine (400 mg) were given to patients with cardiac disease before and after one month of therapy with amiodarone, 400 mg daily. The kinetic profile of carbamazepine, its free fraction, and serum amiodarone, were measured at the two occasions. There was no statistically significant change in carbamazepine kinetics or free fraction, before and after the introduction of amiodarone. The concentrations of amidarone after one month of therapy were low. It is sugested that the possible interaction in the hepatic metabolism was not demonstrated because amiodarone concentrations were not enough to inhibit carbamazepine metabolism.

Keywords : amiodarone; carbamazepine; epilepsy; antiepileptic drags; arrythmia.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License