SciELO - Scientific Electronic Library Online

 
vol.53 issue4Comparative study of HDL and LDL cholesterol as risk factors for carotid atherosclerosisPattern reversal visual evoked potential abnormalities in patients with defined multiple sclerosis author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Abstract

ROCHA, Maria Sheila G.; ANDRADE, Luiz Augusto F.; FERRAZ, Henrique B.  and  BORGES, Vanderci. Levodopa-induced dyskinesias in 176 parkisonian patients. Arq. Neuro-Psiquiatr. [online]. 1995, vol.53, n.4, pp.737-742. ISSN 0004-282X.  https://doi.org/10.1590/S0004-282X1995000500004.

Dyskinesias are frequently observed in parkinsonian patients during levodopa treatment. The occurrence of these movement disorders usually makes the therapeutic management of the patients very difficult. The clinical characteristics of 176 patients with dyskinesias were retrospectively studied. Dyskinesias occurred, on average, after 6,2 years of duration of Parkinson's disease and after 4.2 years on treatment with levodopa. Patients were more likely to have dyskinesias during more advanced stages (measured by Hoehn and Yahr scale). Peak of dose and square wave were the types of dyskinesia more frequently described and were associated with choreic movements in most cases. Dystonia occurred in 40% of the cases and was predominant in end of dose and diphasic dyskinesias. Thirty-five percent of dystonia cases presented as "early morning dystonia". Chorea was the most frequent involuntary movement and mostly generalized. Dystonia was most commonly described in lower limbs. Orofacial dyskinesia, when occurred alone, was more frequently seen in old rather than young patients. When dyskinesia was unilateral it was more likely to occur in the side where Parkinson's disease was more severe.

Keywords : Parkinson's disease; dyskinesias; levodopa.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License