Arquivos de Neuro-Psiquiatria
Print version ISSN 0004-282X
HINRICHSEN, S. L. et al. Cerebrospinal fluid in 50 AIDS patients. Arq. Neuro-Psiquiatr. [online]. 1996, vol.54, n.2, pp. 227-231. ISSN 0004-282X. http://dx.doi.org/10.1590/S0004-282X1996000200009.
Fifty AIDS patients were studied. AH patients had anti-HIV antibodies (ELISA) present and met OPAS/ Caracas punctuation criteria for AIDS cases in adults. Cerebrospinal fluid (CSF) analysis included pressure, cytology (number and cytomorphological aspects), total protein and electrophoresis, glucose and chloride concentration. Bacteriological and mycological investigations were performed as well as agglutination tests for Cryptococcus. Complement fixation, indirect immunoflorescence, passive hemagglutination and/or ELISA tests were performed for syphilis, toxoplasmosis, viral and fungal infections. AH CSF analysis were made in the same laboratory following the same methodology. CSF was alterated in 45 cases (90.0%) of the 50 patients studied. The most important alterations observed were: gammaglobulin (55.5%) and total protein (51.1%) increase, hypercytosis (48.9%) and decrease of chloride concentration (40.0%). HIV antibodies were detected in 42 patients (93.3%). Toxomoplamosis, isolated or associated to other agents, was the most frequent opportunistic infection (57.7%). Cerebrospinal fluid should always be examined in AIDS patients with or without neurological symptoms.
Keywords : AIDS; cerebrospinal fluid; opportunistic infections.