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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Abstract

LEON-S, Fidias E.; COSTA, Carlos Mauricio de Castro  and  GAFFGA, Nicholas. Discrepancy, coincidence or evidence in chronic idiopathic spastic paraparesis throughout the world: a meta-analysis on 2811 patients. Arq. Neuro-Psiquiatr. [online]. 1997, vol.55, n.3B, pp.530-535. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X1997000400002.

HTLV-I has been associated with a chronic idiopatic spastic paraparesis (CHISPA) in man; however, a complete understanding of this association is still debated. We selected the most comprehensible papers on this topic between 1985 and 1996, and found that 1261 out of 2811 patients (44.9%) reported, throughout the world, were HTLV-I positive. The mean age was 39.5 years and there was a female predominance of 1.9:1. These results do not exclude the causality of HTLV-I as a germen associated to CHISPA; however, other causes (e.g., toxic, immunosuppressors) must be considered as participating in the multistep neurodegeneration observed in CHISPA throughout the world.

Keywords : HTLV-I; spastic paraparesis; meta-analysis; retrovirus; environmental cofactors.

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