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Arquivos de Neuro-Psiquiatria

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MEDEIROS, Francisco das Chagas; MEDEIROS, Maria Angelina; RAO, Vietla Satyanarayna  and  FIGUEIREDO, Eberval Gadelha. Effects of misoprostrol on pentylenetetrazol-induced seizures in mice. Arq. Neuro-Psiquiatr. [online]. 1997, vol.55, n.4, pp.677-679. ISSN 0004-282X.

The effects of prostaglandin E - analogue misoprostol on the susceptibility to pentilenetetrazol(PTZ) - induced seizures were examined in mice. Misoprostol (200-800 mg/kg), given subcutaneously 45 min before the subconvulsive dose of PTZ (30 mg/kg, i.p) provoked dose-dependent clonic-tonic seizures (30 to 100%) and mortality in mice. At 300 g/kg, s.c, misoprostol pretreatment significantly (p<0.05) lowered the onset latency to first convulsion as well as the latency to mortality induced by a convulsive dose of PTZ (60 mg/kg, i.p.). At this dose misoprostol was found to lower the CD50 and Ld50 values for PTZ by 21 % and 36% respectively. The results suggest that prostaglandins are likely to lower the threshold for convulsions.

Keywords : seizures; pentylenetetrazol; misoprostol; mice.

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