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Arquivos de Neuro-Psiquiatria

On-line version ISSN 1678-4227


FERRI-DE-BARROS, JOÃO ELIEZER  and  MOREIRA, MARINA. Amyotrophic lateral sclerosis and herpes virus. A curious case report: a cause or casual association?. Arq. Neuro-Psiquiatr. [online]. 1998, vol.56, n.2, pp. 307-311. ISSN 1678-4227.

OBJECTIVE: To present a curious case of amyotrophic lateral sclerosis (ALS). CASE: A forty-seven year old man claimed of paresis in the arms since four years. The electrical study of the muscles and nerves diagnosis was ALS, type Vulpian-Bernardt. The cerebrospinal fluid study revealed an inflammatory process and the positivity of immulogical reactions for Herpes simplex I. The blood-brain barrier study showed the possibility that immulogical response for Herpes simplex I was produced in the spinal fluid space. A magnetic resonance suggested cystic myelopathy of cervical spinal cord expanding from C2 to C4. The patient received endovenous acyclovir for 21 days. Until two months after the medication we did not submit the patient to other subsidiary examinations. DISCUSSION: Until now there is no specific drug treatment for ALS. The notion that there is a "syndrome of ALS" related with various causes may help to treat some patients.

Keywords : amyotrophic lateral sclerosis; herpes virus; drug therapy.

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