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Arquivos de Neuro-Psiquiatria
On-line version ISSN 1678-4227
MIELLI, SYLVIA REGINA et al. Non-Hodgkin lymphoma in adults: protein profile of cerebrospinal fluid and serum in 25 patients. Arq. Neuro-Psiquiatr. [online]. 1998, vol.56, n.4, pp. 769-771. ISSN 1678-4227. http://dx.doi.org/10.1590/S0004-282X1998000500011.
Twenty-five non-Hodgkin's adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were colleted in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an incidence of neurologic signs and symptoms in 48% of all patients. Samples analysis showed: increase of total protein in CSF in 52%; local synthesis of IgG in one HIV seropositive patient; IgG concentration increase in the CSF in the absense of malignant cells in the CSF in two patients that clinically improved after chemotherapy; oligoclonal bands only in the CSF in one HTLV-I seropositive patient. These data show that the study of CSF protein profile can contribute in the characterization of CNS involvement in non-Hodgkin lymphoma.
Keywords : non-Hodgkin's lymphoma; protein profile; cerebrospinal fluid.