Abstract

FILARDI, SILVANA; GUERREIRO, CARLOS A.M.; MAGNA, LUIS ALBERTO  and  MARQUES NETO, JOÃO FRANCISCO. Bone mineral density, vitamin D and anticonvulsant therapy. Arq. Neuro-Psiquiatr. [online]. 2000, vol.58, n.3A, pp. 616-620. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X2000000400003.

The aim of this study was to assess bone mineral density and vitamin D metabolism in patients on chronic anticonvulsant therapy. METHODS: Sixty-nine men, outpatients on chronic anticonvulsant therapy, who had been treated for at least 5 years, were studied, comparing them to thirty healthy controls. Bone mineral density was measured as well as serum levels of calcium, ionized calcium, alkaline phosphatase, PTH, 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol. RESULTS: No differences in bone mineral density, serum levels of vitamin D and intact-PTH were observed between patients and controls. Bone mineral density was not associated with chronic anticonvulsant therapy. CONCLUSION: Those adult patients who were on chronic anticonvulsant therapy and who lived in low latitude regions had normal bone mineral density as well as vitamin D serum levels.

Keywords : vitamin D; calcium; anticonvulsant; bone mineral density.