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Arquivos de Neuro-Psiquiatria

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Abstract

TATSUI, Cláudio Esteves et al. Central nervous system granulocytic sarcoma after bone marrow transplant: case report. Arq. Neuro-Psiquiatr. [online]. 2002, vol.60, n.3B, pp. 852-855. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X2002000500031.

Granulocytic sarcoma is a solid tumor, composed by granulocytic precursor cells at various levels of differentiation, located at an extra-medullary site. It is associated with acute myeloid leukemia, and its presence reveals a bad prognostic factor. The treatment usually consists of radiotherapy and chemotherapy. A case of an intracranial granulocytic sarcoma occurring six months after a bone marrow transplant in a patient with acute myeloid leukemia is reported. The patient presented with headache and left hemiplegia caused by a large fronto-parietal lesion with significant mass effect. After a complete surgical resection there was a full recovery of the deficit. The patient completed radiotherapy and chemotherapy with no evidence of disease after three months of follow-up. Surgery is indicated in the presence of progressive neurological deficit. Surgical decompression may provide rapid improvement and therefore, affect quality of survival.

Keywords : granulocytic sarcoma; bone marrow transplant; acute myeloid leukemia; brain tumor.

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