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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282XOn-line version ISSN 1678-4227


ARAUJO, Eduardo José de Almeida; SANT'ANA, Débora de Mello Gonçales; MOLINARI, Sônia Lucy  and  MIRANDA NETO, Marcílio Hubner de. Effect of protein and vitamin B deficiency on the morpho-quantitative aspects of the myenteric plexus of the descending colon of adult rats. Arq. Neuro-Psiquiatr. [online]. 2003, vol.61, n.2A, pp.226-233. ISSN 0004-282X.

We carried out this work with the purpose of studying the effects of protein and vitamin B deficiency on the morphologic and quantitative aspects of the myenteric plexus of the descending colon of adult Rattus norvegicus. Twenty-eight rats were divided in two groups, one of them receiving chow with 22% protein level (control) and the other fed with chow having 8% protein level without vitamin B supplementation, during 120 days. Whole-mounts of the descending colon were prepared and stained with Giemsa, NADH-diaphorase and NADPH-diaphorase. The undernourished rats had a body weight 11.84% less than the control group. Relative to the controls, the experimental group had a colonic area 48% smaller, 51.9% less Giemsa-stained neurons, 28.3% less NADH-diaphorase positive neurons and 24.2% less NADPH-diaphorase positive neurons.

Keywords : enteric neurons; protein malnutrition; descending colon; vitamin B; myenteric plexus.

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