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Arquivos de Neuro-Psiquiatria

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Abstract

LEVI, Guido C. et al. Central nervous system involvement by histoplasmosis as the unique manifestation of this disease in immunocompetent patients: presentation of two cases. Arq. Neuro-Psiquiatr. [online]. 2003, vol.61, n.3B, pp. 859-863. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X2003000500029.

We present two patients with central nervous system involvement as the unique clinical manifestation of histoplasmosis. A clinical review confirmed the infrequency of this form of the disease, overall in childhood, being one of these cases the youngest in Brazilian reports. Comments about the diversity of clinical presentation and main differential diagnosis are presented. We analyze the serologic and cerebrospinal fluid results and, finally, discuss the drugs and duration of treatment.

Keywords : cerebral histoplasmosis; chronic meningitis; antifungal therapy.

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