Arquivos de Neuro-Psiquiatria
Print version ISSN 0004-282X
RONDINELLI, Patrícia Imperatriz Porto; OSORIO, Carlos Alberto Martinez and LOPES, Luís Fernando. Primary intracranial germ cell tumors in children: evaluation of fourteen cases. Arq. Neuro-Psiquiatr. [online]. 2005, vol.63, n.3b, pp. 832-836. ISSN 0004-282X. http://dx.doi.org/10.1590/S0004-282X2005000500021.
This study evaluates the diagnosis, therapy and survival of 14 patients with primary intracranial germ cell tumors during the period from 1991 to 2001. There were 11 males and 3 females. Mean age was 12.2 years old (20 days-18 years). On admission, the most common symptoms were headache (10/14), vomiting (6/14) and visual (6/14). The tumor was in pineal and hypothalamic region in 10 cases, suprasellar in 3 cases, and in the cerebral parenchyma in 1 case. Histologically there were 1 embryonal carcinoma, 5 germinomas, 2 mature teratomas, 1 immature teratoma and 5 mixed germ cell tumors. Treatment differed among the patients according to the type of tumor. Three patients died after tumor progression or relapse and one patient died from another condition. The remaining patients are alive and without disease.
Keywords : brain neoplasm; malignant germ-cell tumor; germinoma.