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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282XOn-line version ISSN 1678-4227

Abstract

MUNIZ, André Luiz et al. Association of cytokines, neurological disability, and disease duration in HAM/TSP patients. Arq. Neuro-Psiquiatr. [online]. 2006, vol.64, n.2a, pp.217-221. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X2006000200009.

OBJECTIVE: To identify clinical and immunological markers associated with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). METHOD: 237 HTLV-I infected individuals were clinically assessed. They were classified according to the Expanded Disability Status Scale (EDSS) and Osame’s Motor Disability Score (OMDS). Cytokine levels were determined in HTLV-I seropositive individuals. RESULTS: 37 patients had HAM/TSP. There was a correlation between the degrees of disability assessed by both scales. There was also a correlation between the duration of HAM/TSP and the severity of disability assessed by either EDSS or OMDS. Higher levels of IFN-g were detected in unstimulated peripheral blood mononuclear cells (PBMC) from HAM/TSP patients as compared with HTLV-I carriers. CONCLUSION: This study shows the validity of the neurological scales to classify the degree of neurological disability in HTLV-I carriers and suggests a progressive behavior of HAM/TSP. This study also shows that IFN-g in PBMC supernatants are markers of HAM/TSP.

Keywords : human T-lymphotropic virus 1; nervous system diseases; cytokines; neurological disability.

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