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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282XOn-line version ISSN 1678-4227

Abstract

SCOLA, Rosana Herminia; PEREIRA, Eduardo Rafael; LORENZONI, Paulo José  and  WERNECK, Lineu César. Toxic myopathies: muscle biopsy features. Arq. Neuro-Psiquiatr. [online]. 2007, vol.65, n.1, pp.82-86. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X2007000100018.

Several drugs and toxic substances can cause muscular abnormalities and are frequent causes of acquired myopathies. We present a series of 32 patients, predominance of young adult patients, diagnosed with toxic myopathy. The most common substances inducing myopathy were corticosteroids (56.2%) followed by the propoxyphene, neuroleptics, zidovudine and drug-induced hypokalemia. The investigation showed normal serum creatine kinase levels in 65.4%, myopathic pattern of the needle electromyography in 40% and the more frequent histological diagnosis of the muscle biopsy was type 2 fiber atrophy (59.3%). Clinical features, etiology, course of the disease, serum levels of muscular enzymes, electromyographic features and, especially, muscle biopsy features are discussed.

Keywords : myopathy; drug; iatrogenic myopathy; toxic myopathy; muscle biopsy.

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