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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282XOn-line version ISSN 1678-4227

Abstract

VASCONCELLOS, Luiz Felipe Rocha et al. Psycothic syndrome developing into dementia as a clinical manifestation of mitochondrial DNA deletion. Arq. Neuro-Psiquiatr. [online]. 2007, vol.65, n.1, pp.114-117. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X2007000100023.

The manifestations of mitochondrial disease are variable, affecting more frequently the organs with high aerobic metabolism in which they are more abundant, for example the nervous system. The beginning of symptoms in general is observed at chilhood, but some patients presented on adult age. We present an atypical case associated with mitochondrial DNA deletion. A 39-years-old man with psychiatric symptoms that configured initial clinical picture and only after 12 years of the beginning of symptoms neurological alterations became noticeable. The diagnosis of mitochondrial illness was confirmed by muscle biopsy being documented mitochondrial DNA deletion.

Keywords : dementia; psychotic syndrome; mitochondriopathy; genetic.

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