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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282XOn-line version ISSN 1678-4227

Abstract

HENRIQUES-SOUZA, Adélia Maria de Miranda; ATAIDE JUNIOR, Luiz  and  LAURENTINO, Silvia Gomes. Treatment of West syndrome with vigabatrin: clinical and electroencephalographic evaluation of 13 patients. Arq. Neuro-Psiquiatr. [online]. 2007, vol.65, n.1, pp.114-149. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X2007000100029.

We evaluated the efficacy of vigabatrin (VGB) as a first drug to be used as monotherapy for West syndrome (WS), its side effects and correlations with the electroencephalogram (EEG). The sample consisted of 13 infants examined between October 2001 and September 2002 at IMIP ambulatory patients’ office or private clinic. Administration of vigabatrin was around 118 mg/kg/day. Suppression of spasms was obtained in 4 children (31%), partial control in 3 (23%), 5 of them did not present therapeutic response (38%) and just one (8%) got worse. On the two patients with tuberous sclerosis, one was seizure-free and in another there was partial control. Side effects happened in 8 children (62%) and consisted of irritability, insomnia, somnolence and agitation, and all of them have been well tolerated. The second EEG showed disappearance of hipsarrhythmia in 6 patients (46%). Four of these were seizure-free. We conclude that VGB is effective and well tolerated as initial monotherapy for WS.

Keywords : West syndrome; hipsarrhythmia; vigabatrin.

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