Arquivos de Neuro-Psiquiatria
Print version ISSN 0004-282X
AREZA-FEGYVERES, Renata et al. Dementia Pugilistica with clinical features of Alzheimer's disease. Arq. Neuro-Psiquiatr. [online]. 2007, vol.65, n.3b, pp. 830-833. ISSN 0004-282X. http://dx.doi.org/10.1590/S0004-282X2007000500019.
A 61-year-old ex-boxer presented with a three-year history of progressive memory decline. During a seven-year follow-up period, there was a continuous cognitive decline, very similar to that usually observed in Alzheimer's disease. Parkinsonian, pyramidal or cerebellar signs were conspicuously absent. Neuropathological examination revealed the typical features of dementia pugilistica: cavum septi pellucidi with multiple fenestrations, numerous neurofibrillary tangles in the cerebral isocortex and hippocampus (and rare senile plaques). Immunohistochemistry disclosed a high number of tau protein deposits and scarce beta-amyloid staining. This case shows that dementia pugilistica may present with clinical features practically undistinguishable from Alzheimer's disease.
Keywords : dementia; dementia pugilistica; punch drunk; Alzheimer's disease; chronic traumatic encephalopathy; parkinsonian [motor signs]; neuropathology.