Arquivos de Neuro-Psiquiatria
Print version ISSN 0004-282X
On-line version ISSN 1678-4227
ARAUJO, Abelardo Q.C.; LEITE, Ana Claudia C.; LIMA, Marco Antonio S.D. and SILVA, Marcus Tulius T.. HTLV-1 and neurological conditions: when to suspect and when to order a diagnostic test for HTLV-1 infection?. Arq. Neuro-Psiquiatr. [online]. 2009, vol.67, n.1, pp.132-138. ISSN 0004-282X. http://dx.doi.org/10.1590/S0004-282X2009000100036.
HTLV-1 is a retrovirus associated with a myriad of clinical conditions, especially hematological and neurological ones. Regarding nervous system diseases, it is of utmost importance to select those cases in which HTLV-1 infection could really be associated. This is particularly true for patients from endemic areas and for HIV-infected patients and drug users, since that these groups are at a higher risk for HTLV infection. This caution in selecting neurological patients for HTLV diagnostic tests is justified by the fact that in some circumstances the seropositivity may merely represent an epiphenomenon. In this paper we enroll some neurological conditions that have been associated with HTLV-1/2 infection in the literature and discuss the real need for HTLV-1/2 diagnostic tests in each one. Because HIV/HTLV-co-infected patients seem to be at an increased risk for neurological diseases development, a special consideration about this matter is also made.
Keywords : HTLV; myelopathy; myopathy; peripheral neuropathy; HIV.