SciELO - Scientific Electronic Library Online

 
vol.67 issue1HTLV-1 and neurological conditions: when to suspect and when to order a diagnostic test for HTLV-1 infection?Congenital muscular dystrophy. Part I: a review of phenotypical and diagnostic aspects author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Arquivos de Neuro-Psiquiatria

On-line version ISSN 1678-4227

Abstract

SCORZA, Fulvio A. et al. Could sudden cardiac death in epilepsy be related to the occurrence of thalamic dysfunction or anatomic change?. Arq. Neuro-Psiquiatr. [online]. 2009, vol.67, n.1, pp. 139-143. ISSN 1678-4227.  http://dx.doi.org/10.1590/S0004-282X2009000100037.

Sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death in people with chronic epilepsy. Its physiopathology is still unknown; however, the most commonly suggested potential mechanisms involve cardiac or respiratory abnormalities. As the anatomical substrate of epileptic activity in the central nervous system (CNS) shows a direct relationship with cardiovascular alterations, this may suggests that patients with epilepsy associated with focal CNS lesions may be at particular risk of SUDEP. Currently, experimental and clinical data support an important role for thalamic nuclei in the behavioural manifestations, initiation and propagation of seizures. In view of the above findings, we purpose that SUDEP, at least in some cases, could be related to the occurrence of thalamic dysfunction or anatomic change.

Keywords : epilepsy; cardiovascular abnormalities; heart; thalamus; sudden unexpected death in epilepsy.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License