SciELO - Scientific Electronic Library Online

 
vol.69 issue1Cystic craniopharyngioma: intratumoral chemotherapy with alpha interferonNeuropathic pain characteristics in patients from Curitiba (Brazil) with spinal cord injury author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Abstract

PIOVESAN, Elcio Juliato et al. Botulinum toxin type-A effect as a preemptive treatment in a model of acute trigeminal pain: a pre-clinical double-blind and placebo-controlled study. Arq. Neuro-Psiquiatr. [online]. 2011, vol.69, n.1, pp. 56-63. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X2011000100012.

The purpose of this study was to investigate if botulinum neurotoxin type-A (BoNT/A) had a preemptive antinociceptive effect in a formalin-induced orofacial pain model (FT). To test this hypothesis, male Rattus norvegicus were injected with isotonic saline solution 0.9% or BoNT/A administered as a 40 μl bolus, lateral to their nose, at 24 hours, 8, 15, 22, 29 or 36 days pre-FT. The procedures were repeated 42 days later. Influence on motor activity was assessed through the open-field test. Pain scores corresponded to the time spent rubbing and flicking the injected area. Animals pre-treated with BoNT/A at the first protocol (8 days subgroup) showed reduced inflammatory scores (p=0.011). For the other groups no significant results were observed at any phase. Motor activity was similar in both groups. BoNT/A showed to be effective preventing inflammatory pain up to eight days after the first treatment, an effect not reproduced on the second dose administration.

Keywords : antinociceptive effect; orofacial pain; preemptive treatment; botulinum neurotoxin type-A.

        · abstract in Portuguese     · text in English     · pdf in Englishpdf in English