Arquivos de Neuro-Psiquiatria
Print version ISSN 0004-282X
OLIVAL, Guilherme Sciascia do; LIMA, Leonardo Ciciarelli Pereira; LIMA, Gabriel Paiva Silva and TILBERY, Charles Peter. Clinical predictors of response to immunomodulators for multiple sclerosis. Arq. Neuro-Psiquiatr. [online]. 2012, vol.70, n.1, pp. 12-16. ISSN 0004-282X. http://dx.doi.org/10.1590/S0004-282X2012000100004.
OBJECTIVES: To determine, based on clinical criteria, the proportion of multiple sclerosis (MS) patients responsive to immunomodulators (RI) and nonresponsive to immunomodulators (NRI), and to ascertain whether clinical and epidemiological data differs between RI and NRI patient groups. METHODS: Patients were assessed on rate of exarcerbations per year, for the period before and after commencement of treatment. The RI and NRI groups were compared for several clinical and epidemiological characteristics. DISCUSSION AND CONCLUSION: A total of 31.4% of the patients were nonresponders to the immunomodulatory treatment. The main predictors of immunomodulatory response were early diagnostic and commencement of therapy and high rate of annual exacerbations prior to treatment. Given the arsenal of medication options available for MS management, screening potential candidates for different therapeutic approaches are critical to optimize evolution of patients with the disease.
Keywords : multiple sclerosis; immunomodulators; predictors.