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Arquivos de Neuro-Psiquiatria

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Abstract

SLATER, Carla Maria Sena Andrade; RIBEIRO, Luiz Claudio Pereira  and  PUCCIONI-SOHLER, Marzia. Difficulties in HAM/TSP diagnosis. Arq. Neuro-Psiquiatr. [online]. 2012, vol.70, n.9, pp. 686-690. ISSN 0004-282X.  http://dx.doi.org/10.1590/S0004-282X2012000900007.

The World Health Organization recommends the use of Osame's criterion (1990) for the diagnosis of HTLV-I-associated myelopathy (HAM/TSP). In 2006, a group of neurologists developed a Brazilian criterion that can diagnose HAM/TSP from its onset. OBJECTIVE: It was to test the agreement between both criteria. METHODS: The study included evaluation of clinical and laboratory findings of 35 patients. The ELISA, Western blot and/or polymerase chain reaction was used to search for anti-HTLV-I antibodies. The analysis of agreement was based on the calculation of Kappa. RESULTS: Concordance of 100% (Kappa=1) occurred in cases of "defined" HAM/TSP, but not in patients with "probable" diagnosis. CONCLUSION: The Brazilian criteria was as effective as Osame's criteria for the diagnosis of "defined" HAM/TSP. However, both require more specific biological markers in cerebrospinal fluid for the laboratory diagnosis of probable cases.

Keywords : HAM/TSP; Human T-lymphotropic virus 1; diagnosis.

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