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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282XOn-line version ISSN 1678-4227


NASCIMENTO, Osvaldo J M. Leprosy neuropathy: clinical presentations. Arq. Neuro-Psiquiatr. [online]. 2013, vol.71, n.9B, pp.661-666. ISSN 0004-282X.

Leprosy is a chronic infectious peripheral neuropathy caused by Mycobacterium leprae. The different clinical presentations of the disease are determined by the quality of the host immune response. Early detection of leprosy and treatment by multidrug therapy are the most important steps in preventing deformity and disability. Thus the early recognition of the clinical leprosy presentation is essential. Mononeuritis, mononeuritis multiplex (MM), polyneuritis (MM summation) are the most frequent. The frequent anesthetic skin lesions are absent in the pure neuritic leprosy presentation form. Isolated peripheral nerve involvement is common, including the cranial ones. Arthritic presentation is occasionally seen, usually misdiagnosed as rheumatoid arthritis. Attention should be given to autonomic dysfunctions in leprosy. There are clinical presentations with severe neuropathic pain - painful small-fiber neuropathy. Leprous late-onset neuropathy (LLON) clinical presentation should be considered facing a patient who develop an inflammatory neuropathy many years after a previous skin leprosy treatment.

Keywords : leprosy neuropathy; clinical presentations; pure neuritic form; neuropathic pain; leprosy late-onset neuropathy; arthritic leprosy; autonomic leprosy; review; neuropatia da lepra; apresentações clínicas; forma neural pura; dor neuropática; neuropatia de início tardio; lepra artrítica; neuropatia autonômica; revisão.

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